| 多指标综合加权评分法结合D-最优设计响应面法优选酒川芎的炮制工艺 |
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| 引用本文： | 张婷婷,李艺丹,郑凯旋,赵永峰,陈达,李文兵,胡昌江.多指标综合加权评分法结合D-最优设计响应面法优选酒川芎的炮制工艺[J].中草药,2018,49(15):3639-3644. |
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| 作者姓名： | 张婷婷 李艺丹 郑凯旋 赵永峰 陈达 李文兵 胡昌江 |
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| 作者单位： | 成都中医药大学药学院;四川新绿色药业科技发展有限公司;国家中医药管理局中药配方颗粒质量与疗效评价重点研究室 |
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| 基金项目： | 国家中医药管理局中药标准化项目“川芎等3种中药饮片标准化建设”（ZYBZH-Y-SC-42） |
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| 摘 要： | 目的采用多指标综合加权评分法结合D-最优设计响应面法优选酒川芎的炮制工艺。方法先用单因素实验优化黄酒的稀释倍数及闷润时间,然后以酒川芎炮制工艺的关键因素加酒量、炒制温度和炒制时间为自变量,进行D-最优设计;将川芎炮制后的5种指标成分阿魏酸、藁本内酯、洋川芎内酯A、洋川芎内酯I、3-正丁烯基苯酞的含量进行综合加权评分作为因变量,进行响应面分析,优选酒川芎的炮制工艺。结果确定酒川芎的最优炮制工艺为加酒量20%,闷润75 min,在156℃炒制12 min。同时发现酒炙品中洋川芎内酯A、洋川芎内酯I、3-正丁烯基苯酞的含量有所增加,应该与酒炙有关。结论用多指标综合加权评分法结合D-最优设计响应面法能优选酒川芎的炮制工艺参数,提高炮制工艺的稳定性和重复性,更好地控制酒川芎的内在质量以保证临床用药的有效性。
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| 关 键 词： | 川芎 炮制工艺 D-最优设计响应面法 层次分析法 阿魏酸 藁本内酯 洋川芎内酯A 洋川芎内酯I 3-正丁烯基苯酞 |
| 收稿时间： | 2018/2/20 0:00:00 |
Optimization of processing technology for prepared Chuanxiong Rhizoma by D-optimal response surface methodology with comprehensive weighted of multi-index |
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| ZHANG Ting-ting,LI Yi-dan,ZHENG Kai-xuan,ZHAO Yong-feng,CHEN D,LI Wen-bing and HU Chang-jiang.Optimization of processing technology for prepared Chuanxiong Rhizoma by D-optimal response surface methodology with comprehensive weighted of multi-index[J].Chinese Traditional and Herbal Drugs,2018,49(15):3639-3644. |
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| Authors: | ZHANG Ting-ting LI Yi-dan ZHENG Kai-xuan ZHAO Yong-feng CHEN D LI Wen-bing and HU Chang-jiang |
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| Institution: | College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China,College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China,College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China,College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China,College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China,Sichuan Neo-Green Pharmaceutical Technology Development Co., Ltd., Pengzhou 611930, China and College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;Key Laboratory of Chinese Medicine Formulations Particle Mass and Clinical Evaluation, State Administration of Traditional Chinese Medicine of the People''s Republic of China, Pengzhou 611930, China |
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| Abstract: | |
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| Keywords: | Chuanxiong Rhizoma processing technology D-optimal response surface methodology analytic hierarchy process (AHP) ferulic acid ligustilide senkyunolide A senkyunolide I 3-butylidenephthalide |
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