| 雷公藤甲素阿魏酸醇质体的制备与评价 |
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| 引用本文： | 何良飞,陶玲,管咏梅,陈丽华,朱卫丰,金晨,吴璐.雷公藤甲素阿魏酸醇质体的制备与评价[J].中草药,2018,49(12):2817-2825. |
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| 作者姓名： | 何良飞 陶玲 管咏梅 陈丽华 朱卫丰 金晨 吴璐 |
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| 作者单位： | 江西中医药大学现代中药制剂教育部重点实验室 |
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| 基金项目： | 国家自然科学基金2014年度地区基金资助项目（81460607） |
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| 摘 要： | 目的研究雷公藤甲素阿魏酸醇质体最佳制备工艺,并考察其制剂性能和体外透皮特性。方法 MTT法确定雷公藤甲素与阿魏酸的配伍比例。采用注入法制备雷公藤甲素阿魏酸醇质体,在单因素实验结果的基础上,采用Box-Behnken设计优化处方,并对其粒径、包封率、电位、分析方法学及体外释放行为进行研究。采用改良的Franz扩散池进行醇质体的体外透皮实验。结果雷公藤甲素与阿魏酸的配伍比例为1∶100。醇质体优化处方为乙醇体积分数为20%,磷脂质量分数为2.2%,超声时间为90 s,制备出的醇质体外观为澄清液体,微有蓝色乳光,平均粒径为(46.75±2.39)nm,Zeta电位为(-46.32±3.76)m V,包封率为(67.72±1.10)%。醇质体中阿魏酸、雷公藤甲素的体外透皮行为均符合Higuchi方程。结论醇质体粒径小、分布均匀、稳定性良好,有良好透皮吸收特性,可为雷公藤有效成分的局部透皮制剂开发提供一定依据。
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| 关 键 词： | 雷公藤甲素 阿魏酸 醇质体 Box-Behnken设计 体外透皮 Higuchi方程 |
| 收稿时间： | 2018/5/20 0:00:00 |
Preparation and evaluation of triptolide and ferulic acid ethosomes |
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| HE Liang-fei,TAO Ling,GUAN Yong-mei,CHEN Li-hu,ZHU Wei-feng,JIN Chen and WU Lu.Preparation and evaluation of triptolide and ferulic acid ethosomes[J].Chinese Traditional and Herbal Drugs,2018,49(12):2817-2825. |
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| Authors: | HE Liang-fei TAO Ling GUAN Yong-mei CHEN Li-hu ZHU Wei-feng JIN Chen and WU Lu |
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| Institution: | Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China,Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China,Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China,Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China,Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China,Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China and Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China |
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| Abstract: | |
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| Keywords: | triptolide ferulic acid ethosomes Box-Behnken design transdermal absorption Higuchi equation |
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