国产促性腺激素释放激素激动剂在体外受精-胚胎移植技术中的应用

目的:探讨国产促性腺激素释放激素激动剂在体外受精胚胎移植技术(invitrofertilization_embryotransfer,IVFET)中的应用。方法:选2000年8月～2001年8月我院门诊不孕症患者58例,采用IVF治疗58个周期,45个周期采用达必佳(Decapeptyl)长方案降调节,13个周期采用阿拉瑞林(Alarilin)长方案降调节,进行超促排卵。结果:58个周期共获卵675个,每周期获卵数目为11.64±2.27个,受精率72.60%,卵裂率82.86%,临床妊娠24例,临床妊娠率为41.38%。达必佳组与阿拉瑞林组,促性腺激素(Gn)用量、受精率、卵裂率、妊娠率,无显著性差异。结论:国产药物促性腺激素释放激素激动剂阿拉瑞林在IVF超促排卵中,起到了很好的降调节作用,具有临床推广应用的价值。

Use of national drug gonadotrophin releasing hormone agonist in vitro fertilization-embroy transfer

Objective: To investigate the effect of national drug gonadotrophin releasing hormone agonist Alarilin in in vitro fertilization-embryo transfer(IVF-ET).Methods: 58 cycles in IVF from Aug.2000 to Aug. 2001 were evaluated. All cycles used long term protocol to superovulation. 45 cycles down regulated with Decapeptyl;13 cycles with Alarilin.Results: 58 cycles obtained 675 eggs , numbers of obtaining eggs in every cycle were 11.64±2.27, fertility rate (72.60 %),cleavage rate (82.86 %),clinical pregnancy 24 cases, clinical pregnancy rate(41.38 %).But there appeared to be no significantdifference between fertilization rate, cleavage rate, clinicalpregnancy rate in each group.Conclusion: The results of our study indicate that Alarilin playes an efficient role of down regulation in controlled ovarian hyperstimulation and provides a practical method for clinical use.