Expression and characterization of equine herpesvirus 1 glycoprotein D in mammalian cell lines |
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| Authors: | J. E. Wellington G. L. Lawrence D. N. Love J. M. Whalley |
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| Affiliation: | (1) School of Biological Sciences, Macquarie University, Sydney;(2) Department of Veterinary Pathology, University of Sydney, New South Wales, Australia |
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| Abstract: | Summary Equine herpesvirus 1 glycoprotein D (EHV-1 gD) expressed constitutively in mammalian cell lines had similar electrophoretic mobility to gD produced in EHV-1 infected cells but lacked a possibly complexed higher molecular weight form seen in the latter. Recombinant gD was N-terminally cleaved at the same site as gD in EHV-1 infected cells and expression was associated with enhanced levels of cell-cell fusion, indicating a role for EHV-1 gD in cell-to-cell transmission of virus. |
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