控释格列吡嗪治疗2型糖尿病22例临床观察

目的 评价控释格列吡嗪治疗２型糖尿病的作用。方法 将３９名２型糖尿病病人随机分为控释格列吡嗪组与格列齐特组。两组药物皆两周调整一次剂量，总疗程１２周。结果 治疗结束后，两组ＨｂＡｌｃ均显著下降（Ｐ〈０．０１）；控释格列吡嗪组第一时相血糖值皆较治疗前明显下降（Ｐ〈０．０１），格列齐特组空腹血糖值较治疗前明显下降（Ｐ〈０．０１），午餐后两小时血糖值较治疗前无明显下降（Ｐ〉０．０５）；其余时相血糖值较治

Clinical trial of glipizide-GITS in the treatment of type 2 diabetes mellitus:a report of 22 cases

Objective To evaluate the effect of glipizide GITS on type 2 diabetes mellitus.Methods 39 patients with type 2 diabetes mellitus were randomly divided into two groups(glipizide GITS group and gliclazide group) for 12 weeks treatment.Dosage was adjusted every two weeks.Results Both drugs reduced HbAlc significantly( P <0.01).In glipizide GITS group,the blood glucose levels in each phase were markedly decreased after treatment( P <0.01).In gliclazide group, the fasting blood glucose levels were significantly decreased ( P <0.01),the levels of 2 hour postprandial blood glucose after lunch were not obviously decreased ( P >0.05),and the levels of blood glucose in other phases were all significantly decreased after treatment ( P <0.05).Fasting insulin levels were decreased in glipizide GITS group and increased in gliclazide group,but those changes were not statistically significant ( P >0.05).The hepatic funcition,renal function and blood routine remained unchanged after the treatments in the two groups.Conclusion Glipizide GITS has a good effect on type 2 diabetes mellitus.