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胚胎移植技术对特种突变小鼠的净化研究
引用本文:李瑞生,董罡,孔德强,吴晓燕,邱正良,仇志华. 胚胎移植技术对特种突变小鼠的净化研究[J]. 实验动物与比较医学, 2005, 0(4): 239-241
作者姓名:李瑞生  董罡  孔德强  吴晓燕  邱正良  仇志华
作者单位:军事医学科学院实验动物中心 北京100071
基金项目:国家科技部专项重大课题资助(2002DEA10010)。
摘    要:目的通过净化特种突变小鼠来建立SPF级种子库。方法利用胚胎移植技术对四种突变无毛小鼠和一种白内障小鼠的桑葚胚进行子宫内移植。结果四种突变无毛小鼠和白内障小鼠均产出仔鼠,获得移植成功,其中白内障小鼠的产仔率最高为25.5%。结论建立了SPF级特种突变小鼠种群,为进一步研究与开发利用提供了可靠保证。

关 键 词:胚胎移植  小鼠  突变无毛  小鼠  白内障  净化
收稿时间:2005-06-02
修稿时间:2004-11-25

Purging Study of Embryonic Transfer in Particular Mutation Mice
LI Rui-sheng,DONG Gang,KONG De-qiang,WU Xiao-yan,QIU Zheng-liang,QIU Zhi-hua. Purging Study of Embryonic Transfer in Particular Mutation Mice[J]. Laboratory Animal and Comparative Medicine, 2005, 0(4): 239-241
Authors:LI Rui-sheng  DONG Gang  KONG De-qiang  WU Xiao-yan  QIU Zheng-liang  QIU Zhi-hua
Affiliation:Department of Electron Microscope, Medical School of Soochow University, Suzhou 215007, China
Abstract:Objective In order to set up particular mutation mice population of SPF by using purging method. Methods Morulae of four mutation hairless mice and one cataract mouse were transplanted into uterus using embryonic transfer method. Results The embryonic transfer was succeeded with birth of infant mice of the four mutation hairless mice and one cataract mouse. The highest rate of success was 25.5% in the birth of cataract mice. Conclusion Particular mutation mice population of SPF has been established, which may provide a reliable support for various research studies and further development utilization.;
Keywords:Embryonic transfer  Mutation   hairless mice  Cataract   mice  Purging
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