| 痛风性关节炎动物模型的研究现状与展望 |
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| 引用本文： | 时乐,徐立.痛风性关节炎动物模型的研究现状与展望[J].实验动物与比较医学,2006(1):71-74. |
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| 作者姓名： | 时乐 徐立 |
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| 作者单位： | 南京中医药大学药理教研室 南京210029 |
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| 摘 要： | 痛风是由于机体嘌呤代谢紊乱,导致血内尿酸增高和/或肾脏排泄尿酸减少,从而引起尿酸盐在组织沉积的疾病,目前尚未见在实验动物中复制出类似人类的痛风性关节炎模型。通过对目前国内外高尿酸血症及痛风模型复制的方法、机制和应用的研究,分析各自的特点及不足之处,并提出复制更加符合临床的高尿酸血症及痛风性关节炎动物模型的展望与设想。
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| 关 键 词： | 关节炎 痛风性 模型 动物 高尿酸血症 |
| 修稿时间： | 2004/11/23 0:00:00 |
Current Status and Prospect for Research on Animal Model of Urarthritis |
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| SHI Le,XU Li.Current Status and Prospect for Research on Animal Model of Urarthritis[J].Laboratory Animal and Comparative Medicine,2006(1):71-74. |
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| Authors: | SHI Le XU Li |
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| Abstract: | Objective Gout is a disease caused by hyperuricemia as a result of disturbance in purin metabolism and/or reduction of excreation of uric acid in the urine.Consequently,uric acid deposits in tissues.Presently,there has not been animal model of urarthritis similar to human gout.In this article the methodology,mechanisms and applications of current animal models of hyperuricemia and urarthritis were reviewed,their characteristics and drawbacks were analyzed,and prospective directions of animal models of hyperuricemia and urarthritis were discussed. |
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| Keywords: | Arthritis gouty Models Animal Hyperuricemia |
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