| PD-L1在头颈部鳞癌中的表达及其临床意义 |
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| 引用本文： | 王迪,曲媛,刘慧颖,张岳,车轶群.PD-L1在头颈部鳞癌中的表达及其临床意义[J].癌症进展,2019,17(1):34-37. |
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| 作者姓名： | 王迪 曲媛 刘慧颖 张岳 车轶群 |
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| 作者单位： | 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院检验科,北京,100021;国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院放射治疗科,北京,100021;北京市朝阳区三环肿瘤医院检验科,北京,100122 |
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| 摘 要： | 目的探讨程序性死亡受体配体1(PD-L1)在头颈部鳞癌(HNSCC)组织中的表达及其临床意义。方法收集69例HNSCC患者的肿瘤组织和外周血标本,应用免疫组织化学法检测肿瘤组织中PD-L1的表达情况,应用免疫透射比浊法检测外周血C反应蛋白(CRP)水平,分析PD-L1表达情况与患者临床特征及外周血CRP水平的关系。结果 HNSCC患者的PD-L1阳性表达率为14.5%(10/69),PD-L1阴性表达和PD-L1阳性表达HNSCC患者的1年内远处转移情况和血管内皮生长因子(VEGF)表达状态比较,差异均有统计学意义(P﹤0.05)。PD-L1阴性表达患者的远处无转移生存情况明显优于PD-L1阳性表达患者(P﹤0.01)。PD-L1阳性表达患者的外周血CRP水平低于PD-L1阴性表达患者(P﹤0.05)。结论 PD-L1可能是HNSCC患者的潜在预后生物标志物,并且与机体的免疫状态密切相关。
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| 关 键 词： | 程序性死亡受体配体1 头颈部鳞癌 C反应蛋白 远处转移 |
Expression of PD-L1 in head and neck squamous cell carcinoma and its clinical significance |
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| WANG Di,QU Yuan,LIU Huiying,ZHANG Yue,CHE YiQun.Expression of PD-L1 in head and neck squamous cell carcinoma and its clinical significance[J].Oncology Progress,2019,17(1):34-37. |
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| Authors: | WANG Di QU Yuan LIU Huiying ZHANG Yue CHE YiQun |
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| Institution: | (Department of Clinical Laboratory,National Cancer Center / National Clinical Research Center for Cancer / Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China;Department of Radiation Oncology,National Cancer Center / National Clinical Research Center for Cancer / Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China;Department of Clinical Laboratory,Beijing Chaoyang District Sanhuan Cancer Hospital,Beijing 100122,China) |
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| Abstract: | WANG Di;QU Yuan;LIU Huiying;ZHANG Yue;CHE YiQun(Department of Clinical Laboratory,National Cancer Center / National Clinical Research Center for Cancer / Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China;Department of Radiation Oncology,National Cancer Center / National Clinical Research Center for Cancer / Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China;Department of Clinical Laboratory,Beijing Chaoyang District Sanhuan Cancer Hospital,Beijing 100122,China) |
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| Keywords: | programmed cell death 1 ligand 1 head and neck squamous cell carcinoma C-reactive protein distant metastasis |
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