| 更昔洛韦防治异基因骨髓移植巨细胞病毒感染 |
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| 引用本文： | 赵恒,邬国和,颜丽华,李东宁,李萍. 更昔洛韦防治异基因骨髓移植巨细胞病毒感染[J]. 实用临床医学(江西), 2005, 6(8): 24-25 |
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| 作者姓名： | 赵恒 邬国和 颜丽华 李东宁 李萍 |
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| 作者单位： | 江西医学院第三附属医院血液科 江西南昌330008(赵恒，邬国和，颜丽华，李东宁)，江西医学院第三附属医院血液科 江西南昌330008(李萍) |
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| 摘 要： | 目的探讨更昔洛韦防治异基因骨髓移植(alloBMT)术后巨细胞病毒(CMV)感染的临床效果。方法对6例alloBMT病人使用更昔洛韦防治CMV感染,预防用药,更昔洛韦5mg/(kg·次),q12h,于术前-9～-1d使用;治疗用药,更昔洛韦5mg/(kg·次),q12h,14～21d,而后每周用药5d维持2～3周。结果6例alloBMT患者术后有3例出现CMV感染,均治愈,随访3～9个月未再出现CMV感染。结论更昔洛韦防治异基因造血干细胞移植术后CMV感染效果良好,早期诊断和治疗更为重要。
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| 关 键 词： | 更昔洛韦 巨细胞病毒 感染 异基因骨髓移植 |
| 文章编号： | 1009-8194(2005)08-0024-02 |
| 修稿时间： | 2005-04-21 |
The Effect of Ganciclovir on Prevention and Treatment of CMV Infection after Allo-BMT |
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| Zhao Heng,WU Guo-he,Yan Li-hua,Li Dong-ling,Li Ping. The Effect of Ganciclovir on Prevention and Treatment of CMV Infection after Allo-BMT[J]. Practical Clinical Medicine, 2005, 6(8): 24-25 |
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| Authors: | Zhao Heng WU Guo-he Yan Li-hua Li Dong-ling Li Ping |
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| Abstract: | Objective:To probe the clinical effect of ganciclovir(GCV) on prevention and treatment of cytomegalovirus (CMV) infection after allogenic bone marrow transplantation (allo-BMT).Methods: Six allo-BMT patients was observed.As preventive medication,each patient was treated with GCV at 5 mg/kg/q12 h from day 9 to day 1 before allo-BMT; as therapeutic medication, each patient who was infected by CMV was treated with GCV at 5 mg/kg/q12 h for 14 to 21 day, then 5 days per week for 2 to 3 weeks sequentially.Results:Three patients were infected by CMV among 6 patients and were cured by GCV. There was no new CMV infection for the next 3 to 9 months with followed-up visit.Conclusion:GCVshows good effect on prevention and treatment of CMV infection after allo-BMT, and an early diagnoses and early treatment is more important. |
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| Keywords: | ganciclovir cytomegalovirus infection allogenic bone marrow transplantation |
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