个体化免疫抑制治疗在肾移植的疗效观察

目的：探讨个体化免疫抑制治疗对肾移植患者的临床价值。方法：将肾移植患者分为个体化组(42例)和常规组(50例)，分别采用个体化免疫抑制治疗和常规免疫抑制治疗，并对术后两组的临床指标进行比较。结果：个体化组比较常规组，术后肝功能损害、高血糖、胃肠功能紊乱、呼吸系统感染、急性排斥反应发生率均明显降低(P＜0．05)；而巨细胞病毒感染发生率及移植肾切除人数无差异(P＞0．05)。结论：个体化免疫抑制治疗既能维持免疫抑制效果，又能最大限度减少药物不良反应，对肾移植患者有较好治疗价值。

Individual immunosuppression therapy in kidney transplant recipients

Objective:To evaluate individual immunosuppressive therapy in renal transplantation.Methods:Different clinical marks were measured in renal transplant recipients who were divided into individual group(40 cases) and control group(52 cases) . The former received individual immunosuppressive therapy, and the latter received routine immunosuppressive.Results:The rates of hepatotoxicity, high blood sugar level, function disorder of stomach and intestine, respiratory infection and acute rejection in individual group were much lower than those in control group (P< 0.05). There was no difference in cytomegaloviral infection rate and resect rate of transplant kidney between two groups(P> 0.05).Conclusions:Individual immunosuppressive therapy could maintain efficient immunosuppression and reduce drug related side-effect significantly.