| 北京市老年人Alzheimer病与痴呆家族史关系研究 |
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| 引用本文： | 姚佳红,李辉.北京市老年人Alzheimer病与痴呆家族史关系研究[J].预防医学情报杂志,2001,17(6):434-435. |
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| 作者姓名： | 姚佳红 李辉 |
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| 作者单位： | 1. 三峡大学医学院,宜昌,443003
2. 中国医学科学院基础研究所中国协和医科大学基础医学院流行病学室 |
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| 基金项目： | 中国医学基金会(CMB)提供资金 |
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| 摘 要： | 目的探讨Alzheimer病(AD)和痴呆家族史的关系.方法采用以人群为基础的病例对照研究设计,通过分层分析和Logistic回归分析估计AD与其痴呆家族史之间的联系强度.结果一级亲属有痴呆病史者,患AD危险性显著高于对照人群(OR值为2.82,P<0.01).同时调整年龄和受教育程度后,一级亲属的痴呆家族史仍和AD的发生有显著联系(调整后的OR值为3.517,P<0.01).结论北京市老年人Alzheimer病存在家族聚集性.
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| 关 键 词： | Alzheimer病 家族史 老年性痴呆 流行病学 |
| 文章编号： | 1006-4028(2001)06-0434-02 |
| 修稿时间： | 2001年2月26日 |
AStudy on Family History of Alzheimer's Disease in Beijing |
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| Yao Jia-hong,Li Hui.Three Gorges Medical University,Yichang ,China..AStudy on Family History of Alzheimer's Disease in Beijing[J].Journal of Preventive Medicine Information,2001,17(6):434-435. |
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| Authors: | Yao Jia-hong Li HuiThree Gorges Medical University Yichang China |
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| Institution: | Yao Jia-hong,Li Hui.Three Gorges Medical University,Yichang 443003,China. |
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| Abstract: | Objective To explore the relationship between Alheimer*ss disease and its family history.Methods Stratified analyses and Logistic regression analysis were used to examine the association between AD and its family history exposure in 127 cases and 1060 controls from a population based case-control study.Results The risk of Alheimer*ss disease was significantly higher in those who had at least one first-degree relative with dementia compared with those who had no dementia relatives ( OR =2 82).Adjusted by age and education level,positive family history of dementia still associated with Alheimer*ss disease( OR =3 517).Conclutions This study provides evidnce for family aggragation of Alzheimer*ss disease among the old people in Beijing. |
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| Keywords: | Alheimer*ss disease Family history |
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