Increase of glomerular filtration rate and renal plasma flow by insulin-like growth factor-1 during euglycaemic clamping in anaesthetized rats |
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Authors: | U. BAUMANN T. EISENHAUER H. HARTMANN |
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Affiliation: | Department of Medicine, University of G?ttingen, Germany. |
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Abstract: | Renal function was studied in anaesthetized rats receiving i.v. infusions of recombinant human insulin-like growth factor-I (IGF-I) under euglycaemic clamp conditions. IGF-I increased glomerular filtration rate up to 35% and renal plasma flow up to 100%, this increase being dose dependent with half-maximal stimulation at serum IGF-I concentrations of about 24 pmol ml-1. Renal vascular resistance was reduced up to 50%, filtration fraction decreased up to 30% and urine flow increased up to three fold while arterial blood pressure was unchanged. Renal haemodynamics were affected at serum IGF-I concentrations that did not stimulate total body glucose disposal during euglycaemic clamping. IGF-I seemed to regulate renal function through IGF-I receptors apparently independent of acute changes of glucose metabolism. |
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Keywords: | Dopamine euglycaemic clamping glomerular filtration rate glucose metabolism growth hormone insulin-like growth factor-I renal function renal plasma flow |
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