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E-cadherin的表达与肝细胞癌侵袭和转移的关系
引用本文:洪坚善,彭浩,段小娴. E-cadherin的表达与肝细胞癌侵袭和转移的关系[J]. 基础医学与临床, 2005, 25(12): 1139-1142
作者姓名:洪坚善  彭浩  段小娴
作者单位:广西医科大学,肿瘤医院,胃肠乳腺外科,广西,南宁,530001;广西医科大学,肿瘤医院,病理研究室,广西,南宁,530001
基金项目:广西青年科技基金(0229029)
摘    要:目的研究上皮性钙黏蛋白(E-cadherin)在人肝细胞癌(HCC)中的表达情况,探讨其与肝癌的相关性。方法选择56例有完整随访资料的肝细胞癌及相应癌旁组织标本、20例正常肝组织标本,用RT-PCR方法检测E-cadherinmRNA的表达;用免疫组织化学方法检测E-cadherin的表达。结果①E-cadherin在肝细胞癌组织中的表达显著低于癌旁组织和正常组织(P〈0.05),而在癌旁组织和正常组织中的表达无差异;②E-cadherin在肝癌组织中的表达与术后复发时间呈正相关(P〈0.05),与病理分期呈负相关(P〈0.05);③癌组织中E-cadherin表达与肝外转移呈负相关(P〈0.05);④癌旁组织中E-cadherin表达与术后复发时间呈正相关(P〈0.05)。结论E-cadherin表达缺失或下调与肝癌的分化程度、侵袭转移能力和复发倾向相关,对肝癌临床转归的评估有一定指导意义。

关 键 词:上皮性钙黏蛋白  肝细胞癌  侵袭转移
文章编号:1001-6325(2005)12-1139-04
收稿时间:2005-07-07
修稿时间:2005-09-27

Relationship between expression of E-cadherin and invasion and metastasis of hepatocellular carcinoma
HONG Jian-shan,PENG Hao,DUAN Xiao-xian. Relationship between expression of E-cadherin and invasion and metastasis of hepatocellular carcinoma[J]. Basic Medical Sciences and Clinics, 2005, 25(12): 1139-1142
Authors:HONG Jian-shan  PENG Hao  DUAN Xiao-xian
Affiliation:Dept. Breast - Gastrointestinal Surgery, Cancer Hospital, Guangxi Medical University, Nanning 530001, China
Abstract:Objective To investigate expression of Ecadherin in hepatocellular carcinoma(HCC) and discuss their pertinence.Methods RT-PCR and immunohistochemical analysis technology were used to detect E-cadherin mRNA expression and E-cadherin protein expression respectively in 56 paired HCC and non-HCC liver tissue samples and 20 normal liver tissue samples.Results 1.The level of E-cadherin expression in HCC was significantly lower than that in adjacent non-HCC liver tissue and in normal liver tissue(P<0.05);but no difference was seen between adjacent non-HCC liver tissue and normal liver tissue;2.E-cadherin expression in HCC had a positive correlation with recurrence after surgical treatment(P<0.05) and an inverse correlation with pathological grade(P<0.05);3.There was an inverse correlation between E-cadherin expression in HCC and extrahepatic metastasis(P<0.05);4.Significant positive correlations were found among E-cadherin expression in adjacent non-HCC liver tissue and extrahepatic metastasis(P<0.05).Conclusion Loss and downregulation of E-cadherin have an correlation with degree of tumor differentiation,capability of invasion and metastasis and tendency of recurrence,which may have some instructive significance for the assessment of outcome of HCC.
Keywords:E-Cadherin   Hepatocellular carcinoma   invasion and metastasis
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