Sesquiterpene lactones from Inula britannica and their cytotoxic and apoptotic effects on human cancer cell lines |
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Authors: | Bai Naisheng Lai Ching-Shu He Kan Zhou Zhu Zhang Li Quan Zheng Zhu Nanqun Zheng Qun Yi Pan Min-Hsiung Ho Chi-Tang |
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Institution: | Department of Food Science, Rutgers University, 65 Dudley Road, New Brunswick, NJ 08901, USA. |
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Abstract: | Three new sesquiterpenes (1-3), together with four known sesquiterpene lactones, were isolated from the flowers of Inula britannica var. chinensis. Structures were established on the basis of high-field 1D and 2D NMR methods supported by HRMS. All sesquiterpene lactones were tested for cytotoxicity as well as apoptotic ratio in human COLO 205, HT 29, HL-60, and AGS cancer cells. Compounds 3 and 4, two alpha-methylene gamma-lactone-bearing sesquiterpenes, were modestly active in these assays. |
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