Glutamine attenuates nitric oxide synthase expression and mitochondria membrane potential decrease in interleukin-1β-activated rat hepatocytes |
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| Authors: | Jun Lu Xin-ying Wang and Wen-hao Tang |
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| Institution: | (1) General Surgery Department, Zhongda Hospital, Jiangsu Key Lab of Molecular and Function Image, Southeast University, 87 Dingjiaqiao Road, Nanjing, China;(2) General Surgery Department, Jinling Hospital, Nanjing University, 305 Zhongshang East Road, Nanjing, China; |
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| Abstract: | Background Mitochondrial dysfunction induced by nitric oxide (NO) overproduction is involved in the pathogenesis of organ failure during
many severe diseases. Recently, several experiments have reported that glutamine (Gln) modifies inducible nitric oxide synthase
(iNOS) gene expression which is thought to be responsible for its beneficial effects in critical illnesses. |
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