Chronic benzodiazepine treatment and cortical responses to adenosine and GABA |
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Authors: | Judit Mally J.H. Connick T.W. Stone |
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Affiliation: | aDepartment of Pharmacology, University of Glasgow, Glasgow, U.K. |
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Abstract: | The effects of chronic treatment of mice with clonazepam have been examined on the responses of neocortical slices to adenosine, 5-hydroxytryptamine (5-HT) and γ-aminobutyric acid (GABA). Responses to these agonists were measured as changes in the depolarisation induced byN-methyl-d-aspartate (NMDA). Added to the superfusion medium diazepam blocked responses to adenosine but not 5-HT; this effect was not observed with 2-chloroadenosine or in the presence of 2-hydroxynitrobenzylthioguanosine. GABA was inactive in control slices but chronic treatment with clonazepam induced responses to GABA and enhanced responses to adenosine but not 5-HT. It is suggested that the induction of GABA responses may reflect the up-regulation of GABA receptors, but the increase of adenosine responses by clonazepam implies that there is no simple relationship between adenosine receptor binding and functional responses. |
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Keywords: | Hippocampus Adenosine γ-Aminobutyric acid Purine Benzodiazepine Clonazepam Diazepam |
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