妊娠梅毒母婴传播干预后不良妊娠结局分析

目的了解深圳市启动预防与控制梅毒母婴传播项目(简称梅控项目)后梅毒孕妇不良妊娠结局的发生情况。方法回顾性分析2004年1月-2009年12月在深圳市宝安区妇幼保健院确诊的330例妊娠梅毒的妊娠结局。结果 2004-2009年共检测孕妇67693例,妊娠梅毒阳性率从2004年的8.26‰下降至2009年的4.11‰,不良妊娠结局的发生率从36.92%下降至24.24%,先天梅毒、死胎及不良结局总的发生率均呈现显著下降的趋势(P<0.05)。孕28周前治疗患者不良妊娠结局的发生率显著低于孕28周后治疗的患者及孕期未治疗的患者。结论本区域妊娠梅毒及梅毒孕妇的不良妊娠结局发生率呈逐年下降趋势。对妊娠梅毒进行正确的干预治疗可以显著降低各种不良妊娠结局的发生率。

Adverse Pregnancy Outcomes in Gravidas with Syphilis Treated During Gestation

Objective To analyze the adverse pregnancy outcomes (APOs) in gravidas with syphilis treated during gestation after the launch of the prevention programs of mother-to-child-transmission of syphilis in Shenzhen. Methods A retrospective analysis was conducted about the outcoms of 330 cases of gravidas with syphilis diagnosed in Shenzhen Bao’an Maternal and Child Health Hospital from Jan 2004 to Dec 2009. Results 67 693 pregnant women were screened for syphilis. After the running on of the PPSS, the ratio of APOs in infected women significantly dropped from 36.92% in 2004 to 24.24% in 2009 (P<0.05). The proportions of congenital syphilis and perinatal death were decreased significantly (P<0.05). The frequencies of APOs of women treated before 28-week gestation were significantly lower than those of women treated after 28-week gestation and untreated women. Conclusion Both the prevalence of syphilis in pregnant women and the APOs in them were decreased year by year after the beginning of the PPSS.