舒血宁注射液与临床常用输液的配伍稳定性

 目的 考察舒血宁注射液在5种临床常用输液及葡萄糖注射液中加入胰岛素后配伍稳定性。方法 取临床处方剂量的舒血宁注射液与5种注射液及葡萄糖注射液中加入胰岛素配伍后,考察配伍溶液在室温12 h内溶液颜色、pH值、微粒、黄酮类化合物指纹图谱,银杏内酯A、B、C及总内酯含量。结果 溶液配伍12 h内,溶液颜色及pH值未见变化;与0时相比,粒径≥10和25 μm的不溶性微粒数量符合规定;黄酮类指纹图谱没有明显变化;银杏内酯A、B、C及总内酯含量没有变化。 结论舒血宁注射液可以与5种常用输液及葡萄糖注射液中加入胰岛素配伍。因此,舒血宁注射液可以复配于实验溶液中。

In Vitro Stability of Shuxuening with Representative Infusion Solutions

OBJECTIVE Compatible stability of Shuxuening injection with 5 different infusions and glucose injection with insulin.METHODS Taking Shuxuening injection with 5 different injections and glucose injection with insulin at room temperature,according to the clinical application of dose,study the compatible stability of solution with color,pH,particulates,contents of flavonoid compounds,total lactones,ginkgolides A,B and C.RESULTS Compatiblility of the solution within 12 h,the solution pH and color,compared with begin,showed no change;number of insoluble particles,≥10 and 25 μm size were acceptable;flavonoid fingerprint did not change significantly;ginkgolide A、B、C and total lactone content did not change.CONCLUSION Shuxuening injection was stable for up to 12 h in vitro in 5 different solutions and glucose injection with insulin at room temperature.Therefore,Shuxuening injection can be constituted,mixed with experiment infusion fluids.