甘露醇对维持性血液透析高血压患者氧化应激相关指标的影响

目的:探讨甘露醇对维持性血液透析(MHD)高血压患者氧化应激相关指标的影响。方法:将40例MHD高血压患者随机分为常规透析组和透析+甘露醇组。透析+甘露醇组在常规透析组基础上加用20%甘露醇注射液。于试验前后应用硫代巴比妥酸法检测丙二醛(MDA)、硝酸还原酶法检测一氧化氮(NO)、酶联免疫法检测氧化蛋白产物(AOPP)。结果:治疗后透析+甘露醇组血清中MDA及AOPP浓度较治疗前明显下降(P<0.05),NO浓度较治疗前明显上升(P<0.05);常规透析组血清中MDA、AOPP及NO浓度治疗前后无显著差异(P>0.05)。治疗后,与常规透析组各项指标比较,透析+甘露醇组治疗效果更为显著(P<0.05)。2组均未见严重不良反应发生。结论:甘露醇具有干预MHD高血压患者体内氧化应激水平的作用。

Effects of Mannitol on Oxidative Stress Index in Maintenance Hemodialysis Patients with Hypertension

OBJECTIVE:To evaluate the effects of mannitol on oxidative stress index in maintenance hemodialysis(MHD)patients with hypertension.METHODS:40 MHD patients with hypertension were randomly divided into 2 groups:the conventional hemodialysis group and hemodialysis + mannitol treatment group.The hemodialysis + mannitol treatment group were additionally given 20% mannitol intravenous dripping.Before and after the test,all patients were measured serum concentrations of MDA,NO and AOPP,respectively using thiobarbituric acid method nitrate redactare method,and ELISA method.RESULTS:Compared with before treatment,the MDA and AOPP in serum of the hemodialysis plus mannitol treatment group were significantly decreased after treatment(P<0.05),and the concentration of NO in serum of the hemodialysis + mannitol treatment group was increased significantly after treatment(P<0.05).Compared with before treatment,there was no significant differences in the concentration of MDA,AOPP and NO in serum of the conventional hemodialysis group after treatment(P>0.05).After treatment,every indexes of hemodialysis plus mannitol treatment group were better than conventional hemodialysis groups(P<0.05),There is no serious ADR found in 2 groups.CONCLUSION:Mannitol may have intervened in oxidative stress levels in MHD patients with hypertension.