| 氧化苦参碱生物黏附缓释片在Beagle犬体内的药动学 |
| |
| 引用本文： | 尹莉芳, 王广基, 张陆勇, 赵存婕, 周建平. 氧化苦参碱生物黏附缓释片在Beagle犬体内的药动学[J]. 中国药科大学学报, 2008, 39(6): 523-525. |
| |
| 作者姓名： | 尹莉芳 王广基 张陆勇 赵存婕 周建平 |
| |
| 作者单位： | 1.中国药科大学药剂学教研室;2.中国药科大学药物代谢动力学重点实验室;3.中国药科大学新药筛选中心 |
| |
| 基金项目： | 国家高技术研究发展计划(863计划) |
| |
| 摘 要： | 目的:考察氧化苦参碱生物黏附缓释片在Beagle犬体内的药动学过程。方法:建立LC-MS法同时测定Beagle犬血浆中的氧化苦参碱及其代谢产物苦参碱。采用BAPP 2.3程序估算犬服用市售普通胶囊(参比制剂)和氧化苦参碱生物黏附缓释片(受试制剂)后的药动学参数。结果:氧化苦参碱血药浓度-时间曲线符合双室模型特征。受试制剂的生物利用度为110.9,且cmax降低、tmax延长,具有缓释效果。服用受试制剂后测得苦参碱的量为服用参比制剂后测得量的90.5%。结论:氧化苦参碱生物黏附缓释片与市售普通胶囊相比,生物利用度等效,具有明显的缓释效果。
|
| 关 键 词： | 氧化苦参碱 苦参碱 生物黏附缓释片 药动学 |
Pharmacokinetics of oxymatrine bioadhesive sustained-release tablets in Beagle dogs |
| |
| YIN Li-fang,WANG Guang-ji,ZHANG Lu-yong,ZHAO Cun-jie,ZHOU Jian-ping. Pharmacokinetics of oxymatrine bioadhesive sustained-release tablets in Beagle dogs[J]. Journal of China Pharmaceutical University, 2008, 39(6): 523-525 |
| |
| Authors: | YIN Li-fang WANG Guang-ji ZHANG Lu-yong ZHAO Cun-jie ZHOU Jian-ping |
| |
| Affiliation: | YIN Li-fang1,WANG Guang-ji2,ZHANG Lu-yong3,ZHAO Cun-jie1,ZHOU Jian-ping1 1Department of Pharmaceutics,2Key Laboratory of Drug Metabolism & Pharmacokinetics,3New Drug Screening Center,China Pharmaceutical University,Nanjing 210009,China |
| |
| Abstract: | Aim:To study pharmacokinetics of oxymatrine bioadhesive sustained-release tablets in Beagle dogs.Methods:LC-MS method was established to detect oxymatrine and matrine in plasma of Beagle dogs simultaneously.BAPP 2.3 was applied to analyze the experimental data after Beagle dogs were given commercial tablets as reference and oxymatrine bioadhesive sustained-release tablets as test.Results:Disposition of oxymatrine in Beagle dogs fitted with two-compartment model.The bioavailability of oxymatrine bioadhesive ... |
| |
| Keywords: | oxymatrine matrine bioadhesive sustained-release tablets pharmacokinetics |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《中国药科大学学报》浏览原始摘要信息 |
|
点击此处可从《中国药科大学学报》下载全文 |
