SARS-CoV-2 IgG Seroprevalence among Blood Donors as a Monitor of the COVID-19 Epidemic,Brazil |
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| Authors: | Daniel Gonç alves Chaves,Ricardo Hiroshi Caldeira Takahashi,Felipe Campelo,Maria Clara Fernandes da Silva Malta,Isabelle Rocha de Oliveira,Edel Figueiredo Barbosa-Stancioli,Maí sa Aparecida Ribeiro,Marina Lobato Martins |
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| Affiliation: | Fundação Hemominas, Belo Horizonte, Brazil (D.G. Chaves, M.C.F. da Silva Malta, M.A. Ribeiro, M.L. Martins);Universidade Federal de Minas Gerais, Belo Horizonte (R.H.C. Takahashi, F. Campelo, I.R. de Oliveira, E.F. Barbosa-Stancioli);Aston University, Birmingham, UK (F. Campelo) |
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| Abstract: | During epidemics, data from different sources can provide information on varying aspects of the epidemic process. Serology-based epidemiologic surveys could be used to compose a consistent epidemic scenario. We assessed the seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgG in serum samples collected from 7,837 blood donors in 7 cities of Brazil during March–December 2020. Based on our results, we propose a modification in a compartmental model that uses reported number of SARS-CoV-2 cases and serology results from blood donors as inputs and delivers estimates of hidden variables, such as daily values of SARS-CoV-2 transmission rates and cumulative incidence rate of reported and unreported SARS-CoV-2 cases. We concluded that the information about cumulative incidence of a disease in a city’s population can be obtained by testing serum samples collected from blood donors. Our proposed method also can be extended to surveillance of other infectious diseases. |
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| Keywords: | COVID-19 respiratory infections severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 SARS coronavirus disease zoonoses viruses coronavirus blood donor epidemic model seroprevalence Brazil |
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