乙氧苯柳胺软膏联合卤米松乳膏治疗神经性皮炎疗效观察

目的观察乙氧苯柳胺软膏联合卤米松乳膏治疗神经性皮炎的临床疗效。方法 106例患者随机分为治疗组和对照组各53例,治疗组每日晨起和晚上临睡前外用乙氧苯柳胺软膏各1次,中午外用卤米松乳膏;对照组单纯外用卤米松乳膏,每天2次,均3周为1个疗程,观察2组临床疗效及不良反应。结果治疗1周后治疗组总有效率为28.3%高于对照组的15.1%,差异有统计学意义（P〈0.05）。治疗3周后治疗组总有效率为88.7%高于对照组的62.3%,差异有统计学意义（P〈0.05）。治疗组发生不良反应2例,对照组发生11例均无需停药或特殊处理,不影响继续治疗。结论乙氧苯柳胺软膏联合卤米松乳膏外用治疗神经性皮炎,临床疗效显著,安全性高,不良反应小,值得临床推广应用。

Effect observation of elofesalamide ointment combined with halometasone cream in the treatment of neurodermatitis

Objective To observe the clinical efficacy of elofesalamide ointment combined with halometasone cream in the treatment of neurodermatitis.Methods The 106 cases were randomly divided into treatment group and control group,53 cases of each.The treatment group used elofesalamide ointment externally twice a day,early morning and night before going to sleep,and used halometasone cream externally at noon;The control group merely used halometasone cream externally twice a day,3 weeks as a course of treatment.Observed the clinical efficacy and adverse reactions of 2 groups.Results After treatment for 1 weeks,the total effective rate of of the treatment group was 28.3% higher than 15.1% of the control group,and the difference was statistically significant（P0.05）.After treatment for 3 weeks,the total effective rate of of the treatment group was 88.7% higher than 62.3% of the control group,and the difference was statistically significant（P0.05）.2 patients had adverse reaction in the treatment group,while 11 patients had adverse reaction in the control group,all of the 13 patients did not need to stop taking medicine and special treatment,without prejudice to continuing treatment.Conclusion Treating neurodermatitis with elofesalamide ointment combined with halometasone cream has good clinical effect,high safety and less adverse effect,which is worth clinical popularizing and application.