骨桥蛋白和CD44v6在非小细胞肺癌中的表达及意义

目的：探讨骨桥蛋白（OPN）和CD44v6在非小细胞肺癌中的表达与肺癌临床病理的关系。方法：应用免疫组织化学方法,分别检测OPN和CD44v6在56例非小细胞肺癌（30例鳞癌和26例腺癌）组织中的表达。结果：（1）56例非小细胞肺癌组织中OPN和CD44v6阳性表达率分别为71.4%、67.8%。肺鳞癌组和肺腺癌组中OPN和CD44v6的表达无差异性（P〉0.05）。（2）肺癌中OPN和CD44v6的表达与肿瘤的淋巴结转移相关（P〈0.05）,而与患者的年龄、性别及肿瘤组织学分级无关（P〉0.05）。结论：OPN和CD44v6可能在肺癌的发生、进展中起重要作用,联合检测OPN、CD44v6可作为判断肺癌患者预后的重要指标。

Overexpression of osteopontin and CD44v6 in the non-small cell lung cancer

Objective:To explore the expression and role of osteopontin(OPN) and CD44v6 in the non-small cell lung cancer and analyze the relationship between its expression and clinicopathologic features.Methods:The expression of OPN and CD44v6 was studied by immunohistochemistry in 56 cases of non-small cell lung carcinoma tissues.Results:In 56 cases of non-small cell lung carcinoma tissues,the expression rates of OPN and CD44v6 were 71.4%,67.8%,respectively.There was a strong correlation between the expression of OPN and CD44v6 in non-small cell lung cancer,it was obviously related with tumor degree of lymphatic vessel invasion or long distant lymph node metastases(P<0.05).Conclusion:OPN and CD44v6 may play an important role in the progression of non-small cell lung carcinomas and they may involve in the invasion and metastasis of non-small cell lung carcinomas.