The effect of hormone replacement on physical performance in community-dwelling elderly women |
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Authors: | Greenspan Susan L Resnick Neil M Parker Robert A |
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Affiliation: | a Division of Geriatric Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania b University of Pittsburgh Institute on Aging, Pittsburgh, Pennsylvania c Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania d Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, Mass. |
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Abstract: | PurposeOur aim was to determine the effect of hormone replacement on physical performance measures, functional ability, physical activity, falls, and cognitive function in elderly women.Subjects and methodsFollowing a 3-month, open-label, run-in phase, we randomized 373 community-dwelling women aged 65 years and older to receive conjugated equine estrogen 0.625 mg/day plus or minus medroxyprogesterone 2.5 mg/day vs placebo for 3 years in a double-blind fashion. We assessed time to rise from a chair, timed walking, balance, Instrumental Activities of Daily Living, Physical Activity Scale of the Elderly, Folstein Mini-Mental State Examination, and falls.ResultsOver 3 years, except for balance scores, performance measures declined significantly (all P<.05). There were no significant mean differences between women on hormone replacement versus placebo for rising time (0.1, −0.5 to 0.7 seconds [mean, 95% confidence interval]), walking normal (0.0, −0.4 to 0.4 seconds), and walking fast (0.2, −0.1 to 0.6 seconds). There were no significant mean differences between the two groups for the Instrumental Activities of Daily Living (0.1, −0.1 to 0.3 points), Physical Activity Scale of the Elderly (−3, −15 to 8 points), Folstein Mini-Mental State Examination (−0.1, −0.3 to 0.3 points), or the proportion of participants reporting falls (−1, −11 to 9%).ConclusionIn elderly women, hormone replacement had no statistically significant effect on cognition or balance, nor did it prevent the age-related decline in physical measures of mobility, ability to rise from a chair, self-reported activities of daily living, physical activity scores, or falls. |
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Keywords: | Elderly women Functional assessment Balance Mobility Hormone replacement therapy Cognitive function Physical activity |
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