Effects of levosimendan on markers of left ventricular diastolic function and neurohormonal activation in patients with advanced heart failure |
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Authors: | Parissis John T Panou Fotios Farmakis Dimitrios Adamopoulos Stamatis Filippatos Gerasimos Paraskevaidis Ioannis Venetsanou Koula Lekakis John Kremastinos Dimitrios Th |
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Affiliation: | Second Department of Cardiology and Heart Failure Clinic, Attikon University Hospital, Athens, Greece. |
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Abstract: | In this randomized, placebo-controlled study, it was found that a 24-hour levosimendan infusion improves echocardiographic markers of abnormal left ventricular diastolic function (transmitral flow patterns and mitral annulus velocities, as assessed by transthoracic pulse-wave Doppler and tissue Doppler imaging, respectively) and reduces substances of excessive neurohormonal activation (plasma B-type natriuretic peptide and interleukin-6) in patients with advanced heart failure. Moreover, levosimendan-treated patients had fewer events and longer progression-free survival during a 5-month follow-up compared with those who received placebo. Thus, levosimendan seems to be effective in improving left ventricular diastolic function and reducing neurohormonal activation in patients with severe heart failure. |
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