| 三种有机锗（G－132，Ge－162，Ge－164）对小鼠骨髓嗜多染红细胞微核率的影响 |
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| 引用本文： | 李志道,毛旭峰,张文娟. 三种有机锗（G－132，Ge－162，Ge－164）对小鼠骨髓嗜多染红细胞微核率的影响[J]. 癌变．畸变．突变, 1995, 0(3) |
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| 作者姓名： | 李志道 毛旭峰 张文娟 |
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| 作者单位： | 武汉市职工医学院 |
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| 摘 要： | 本文以三种有机锗（Ｇｅ－１３２，Ｇｅ－１６２．Ｇｅ－１６４）对小鼠进行灌胃处理，以测定对环磷酰胺（ＣＰ）诱发的骨髓嗜多染红细胞微核率的抑制作用，结果表明，三种有机锗均能降低微核率，与阳性对照组比较有显著性差异（Ｐ＜０．０５）．而三种有机锗之间抑制微核率的效能无差异（Ｐ＜０．０５）。提示，三种有机锗均可拮抗ＣＰ的致突变作用。
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| 关 键 词： | 有机锗，小鼠，微核 |
THE EFFECT OF THREE ORGANOGERMANIUM COMPOUNDSON THE PCE MICRONUCLEI IN MOUSE |
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| Li Zhidao,Mao Xufeng,Zhang WenjuanWuhan Medical College For Health Staff.Wuhan. THE EFFECT OF THREE ORGANOGERMANIUM COMPOUNDSON THE PCE MICRONUCLEI IN MOUSE[J]. Carcinogenesis,Teratogenesis and Mutagenesis, 1995, 0(3) |
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| Authors: | Li Zhidao Mao Xufeng Zhang WenjuanWuhan Medical College For Health Staff.Wuhan |
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| Affiliation: | Li Zhidao,Mao Xufeng,Zhang WenjuanWuhan Medical College For Health Staff.Wuhan 430016 |
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| Abstract: | Three of organogermanium compounds(Ge-132,Ge-162 ,Ge-164)were givento rats by oral gavage to study the suppressive effect of organogermanium on the PCE mi-crounclei in mouse induced by CP,The results showed that alI three organogermanium com-pounds(Ge-132,Ge-162,Ge-164)can significant decrease the frequence of micronuleus.No significant difference was found among these three compounds(P>0.05).The results in-dicated these three organogermanium compounds(Ge-132,Ge-162,Ge-164.)possess su-pressive effect on the mutagenic activity of cyclophumide. |
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| Keywords: | organogermanium mouse micronucleus. |
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