硫酸钙/庆大霉素、硫酸钙/聚乳酸/庆大霉素释药系统的制备与特性分析

目的构建新型骨植入型抗生素释放系统，硫酸钙／庆大霉素、硫酸钙／聚乳酸／庆大霉素释药系统，探讨抗生素释放系统的制备可行性。方法以自行研制的硫酸钙或硫酸钙与聚乳酸的复合物作为抗生素载体，构建抗生素释放系统，对其进行电镜扫描，晶体衍射分析和体外降解实验以分析其构成特点、理化特性和降解特点。结果所构建的抗生素释药系统主要成分为二水硫酸钙，具有初始的生物力学抗压缩强度，具有一定的孔隙率，硫酸钙／聚乳酸／庆大霉素中，聚乳酸对硫酸钙形成包裹。体外可降解，硫酸钙／聚乳酸／庆大霉素降解时间长于硫酸钙／庆大霉素。结论以硫酸钙和硫酸钙聚乳酸复合物作为载体构建抗生素释放系统能够满足药物释放和骨内植入的要求，具有制备的可行性。

The development and characteristic analysis of Bone-Implanted Calcium Sulfate/Getamycin and Calcium Sulfate/Polylactic Acid /Getamycin Delivery System

Objective To discuss the feasibility of developing bone-implanted local antibiotic delivery system, CaS/GM and CaS/PLA/GM. Methods Constructing antibiotic delivery system by using calcium sulfate or calcium sulfate/polylactic acid composite as gentamycin vehicle, doing research on the physical-chemical property, biomechanical characteristic, feature of constitute by SEM and X-RD and degradable property of the delivery system in vitro. Results The major constituent of antibiotic delivery system is calcium sulphate dihydrate, both of them have some degree of porosity and initial anti-compressive strength; CaS is encapsulated by PLA in CaS/PLA/GM system, the degradable rate of CaS/PLA/ GM is slower than that of CaS/GM. Conclusion： CaS and CaS/PLA composite are suitable for antibiotic vehicle. The drug delivery system, CaS or CaS/PLA can answer the need for drug delivery and bone implantation.