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The oriented development of antituberculotics: salicylanilides |
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| Authors: | Waisser Karel Matyk Josef Divisová Hana Husáková Petra Kunes Jirí Klimesová Vera Kaustová Jarmila Möllmann Ute Dahse Hans-Martin Miko Milan |
| Institution: | Department of Inorganic and Organic Chemistry, Charles University in Prague, Faculty of Pharmacy, Hradec Králové, Czech Republic. waisser@faf.cuni.cz |
| Abstract: | On the basis of our previous results 22 salicylanilides were synthesized. The compounds were tested for in vitro antimycobacterial activity against Mycobacterium tuberculosis, Mycobacterium kansasii, and Mycobacterium avium. The Free-Wilson method was used to evaluate structure-antimycobacterial activity relationships. 4-Chloro-N-(4-propylphenyl)salicylamide and 5-chloro-N-(4-propylphenyl)salicylamide were selected for preclinical studies. |
| Keywords: | Antimycobacterial activity Antituberculosis activity QSAR Salicylanilides |
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