通心络胶囊治疗冠心病变异性心绞痛临床疗效及对内皮功能的影响

目的:观察通心络胶囊治疗冠心病变异性心绞痛的临床疗效及对内皮功能的影响。方法:选取冠心病变异性心绞痛患者64例,随机分为两组,分别予以通心络胶囊和鲁南欣康治疗4周。结果:(1)通心络可明显改善冠心病变异性心绞痛患者的临床症状,总有效率为8667%,鲁南欣康组总有效率为8710%,两组间无显著性差异;(2)通心络组血清一氧化氮(NO)含量明显增加,血清内皮素(ET)水平降低,与鲁南欣康组比较,两组无显著性差异。结论:通心络胶囊能缓解冠心病变异性心绞痛的临床症状,改善其内皮功能,提示通心络的作用机理之一是通过增加NO,抑制ET而介导的。

Effect of Tongxinluo Capsule in Treating Variant Angina Pectoris Patients and Its Influence on Endothelial Function

To assess the efficacy of Tongxinluo capsule (TXLC) in treating variant angina pectoris and its effect on endothelial function. Methods: Sixty four patients with variant angina pectoris were enrolled in the study for four weeks by a randomized clinical trial treated with TXLC or isosorbide mononitrate. Results: (1) The symptoms of both groups were significantly improved, the total effective rate of TXLC and isosorbide were 86.67% and 87.10% respectively; (2)The level of serum nitric oxide was increased, and the serum endothelin was decreased after treatment, there was no significant difference between these two groups. Conclusion: TXLC could effectively improve the symptoms of variant angina pectoris, the mechanism of which may likely be mediated by nitric oxide and endothelin.