“参归方”中参归的配伍分析

目的：应用文献计量学方法，分析参归方中关键药物参归配比与疾病科属的关系。方法：从中国传统医药古籍中检索出含有参归的49首方剂，并建立数据库，对其药材基源、主治疾病科属和参归配伍比例进行统计分析。结果：49首参归方剂，主要用于治疗内科疾病16次（32.65%）、妇科疾病17（34.69%）次和儿科疾病8次（16.32%），其中“归”全为当归，“参”有3种，人参40次，党参8次，苦参1次；人参-当归二者配比常小于或等于1，党参-当归二者配比常大于1，所治疾病科属以内科和妇科的方剂出现频率最多。结论：运用数据分析方法，能有效发现参归方组方配伍中人参-当归药对的应用特点与规律，为临床用药和新药开发提供理论依据与参考。

Compatibility Analysis of Shen and Gui in Shen-Gui-Fang Formula

This study was aimed to explore the relationship between the Shen-Gui-Fang (SGF) formula of different proportions and treatments for diseases with the method of bibliometrics. A total of 49 formulae of SGF from ancient books of traditional Chinese medicine (TCM) were retrieved and the database was established in order to analyze the origin of herbal medicine and the relationship with the ratio of the key medicinal material, as well as the treatment for major diseases. The results showed that 49 SGF formulae were mainly used in the treatment of internal disorders for 16 times (32.65%), gynecological disorders for 17 times (34.69%) and pediatric disorders for 8 times (16.32%). Gui standed for Angelica sinensis. There were 3 types of Shen, which were Panax ginseng for 40 times, Codonopsis pilosula for 8 times, and Sophora flavescens for 1 time. The ratio between P. ginseng and A. sinensis was less or equal to 1. The ratio between C. pilosula and A. sinensis was usually more than 1. The formulae with the highest frequency were in the treatment of internal medicine and gynecological diseases. Statistical analysis was used to find the application features and rules of the combination of P. ginseng and A. sinensis in SGF formula, in order to provide theoretical evidences and references for clinical medication selection and new medication research.