| 中药作用于血脑屏障的研究进展 |
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| 引用本文： | 王一,赵彤,于蓓蓓,胡谦锋,张曦,周春祥. 中药作用于血脑屏障的研究进展[J]. 世界科学技术-中医药现代化, 2015, 17(7): 1525-1529 |
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| 作者姓名： | 王一 赵彤 于蓓蓓 胡谦锋 张曦 周春祥 |
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| 作者单位： | 南京中医药大学基础医学院 南京 210046,第二军医大学附属长海医院 上海 200433,南京中医药大学基础医学院 南京 210046,南京中医药大学基础医学院 南京 210046,南京中医药大学基础医学院 南京 210046,南京中医药大学基础医学院 南京 210046；南京中医药大学明基教学医院 南京 210036 |
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| 基金项目： | 国家自然科学基金委面上项目（8127639）：基于三物白散逆转荷瘤机体Th1/Th2漂移探讨“祛邪以扶正”治则应用规律，负责人：周春祥。 |
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| 摘 要： | 血脑屏障是机体内的一种重要的屏障系统，它可以有选择地阻止某些物质进入大脑，从而保持中枢神经系统内环境的相对稳定，但这也成为药物治疗中枢神经系统疾病的重要制约因素。中药对多种中枢神经系统疾病均具有良好的疗效，这说明其有效成分可以透过血脑屏障或影响血脑屏障的功能。本文归纳和总结了目前中药作用于血脑屏障的药理和临床试验研究方面的文献资料并对此进行综述。
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| 关 键 词： | 中药 血脑屏障 通透性 中枢神经系统 |
| 收稿时间： | 2015-01-14 |
| 修稿时间： | 2015-04-08 |
Research Progress of Traditional Chinese Medicine on Blood-brain Barrier |
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| Wang Yi,Zhao Tong,Yu Beibei,Hu Qianfeng,Zhang Xi and Zhou Chunxiang. Research Progress of Traditional Chinese Medicine on Blood-brain Barrier[J]. World Science and Technology—Modernization of Traditional Chinese Medicine and Materia Medica, 2015, 17(7): 1525-1529 |
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| Authors: | Wang Yi Zhao Tong Yu Beibei Hu Qianfeng Zhang Xi Zhou Chunxiang |
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| Affiliation: | Basic Medicine College, Nanjing University of Chinese Medicine, Nanjing 210046, China,Changhai Hospital Affiliated to Second Military Medical University, Shanghai 200433, China,Basic Medicine College, Nanjing University of Chinese Medicine, Nanjing 210046, China and Basic Medicine College, Nanjing University of Chinese Medicine, Nanjing 210046, China;Nanjing BenQ Teaching Hospital, Nanjing University of Chinese Medicine, Nanjing 210036, China |
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| Abstract: | Blood-brain barrier (BBB) is a kind of important barrier system in the body. It can have a choice to prevent certain substances from entering the brain, in order to maintain the relative stability of internal environment of the central nervous system (CNS). However, it also became an important restriction factor for the treatment of CNS diseases. Traditional Chinese medicine (TCM) had good curative effects on several kinds of CNS diseases, which illustrated that effective composition of TCM can pass through or influence the function of BBB. This paper summarized the research progress of literatures on current pharmacological and clinical trials for the effect of TCM on BBB. |
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| Keywords: | Traditional Chinese medicine blood-brain barrier permeability central nervous system |
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