Report: workshop on mediastinal grey zone lymphoma |
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| Authors: | Sibrand Poppema,Joost L Kluiver,Cigdem Atayar,Anke van,den Berg ,reas Rosenwald,Michael Hummel,Dido Lenze,Hetty Lammert,Harald Stein,Stephan Joos,Thomas Barth,Martin Dyer,Peter Lichter,Uwe Klein,Giorgio Cattoretti,Annunziata Gloghini,Yuhai Tu,Gustavo A Stolovitzky,rea Califano,Antonino Carbone,Ricardo Dalla-Favera,Ingo Melzner,Alexandra J Bucur,Silke Brü derlein,Karola Dorsch,Cornelia Hasel,Thomas FE Barth,Frank Leithä user,Peter Mö ller |
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| Affiliation: | Department of Pathology and Laboratory Medicine, University Medical Center Groningen, University of Groningen, The Netherlands;;Department of Pathology, University of Wirzburg, Germany;;Institute of Pathology, Charité–University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany;;Deutsches Krebsforschungszentrum, Department of Molecular Genetics, Heidelberg, Germany;;Department of Pathology, University of Ulm, Germany;;MRC Toxicology Unit/Leicester University, Leicester, UK;;Institute for Cancer Genetics, Columbia University, New York, NY, USA;;Division of Pathology and Medical Oncology A, National Cancer Institute, Aviano, Italy;;IBM T.J. Watson Research Center, Yorktown Heights, NY, USA and Center for Computational Biology and Biochemistry, Columbia University, New York, NY, USA |
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| Abstract: | Abstract: There are several indications that classical Hodgkin lymphoma (cHL) and at least a proportion of cases of Primary Mediastinal B cell Lymphoma (PMBL) are derived from B cells at similar stages of differentiation and share common pathogenic mechanisms. The first indication was the existence of mediastinal grey zone lymphomas as identified in the 4th International Symposium on HL, with clinical, histological and immunohistochemical features intermediate between cHL and PMBL. Second, both tumor types resemble a cell that is developmentally situated in-between the germinal center reaction and a plasma cell. Third, cHL and PMBL were found to have similar gene expression profiles, including the lack of immunoglobulin expression and low levels of B cell receptor signalling molecules, and the secretion of molecules like the chemokine TARC and the prominent expression of IL-13 receptors. Fourth, both entities were found to have common genomic aberrancies, notably in 2p15 and 9p24, the sites of the REL oncogene and the tyrosine kinase gene JAK2, respectively. Further comparison of both lymphoma types may provide further insight in the pathogenic mechanisms and allow the design of diagnostic algorithms to sort out the small number of so-called mediastinal grey zone lymphomas, that appear to be intermediate between PMBL and cHL. |
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| Keywords: | Mediastinal grey zone lymphoma Primary mediastinal B cell lymphoma Classical Hodgkin lymphoma gene expression profiling TARC REL |
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