奎硫平与利培酮治疗精神分裂症的对照研究

目的探讨奎硫平治疗精神分裂症的效果与不良反应。方法将90例精神分裂症患者随机分为奎硫平治疗组和利培酮治疗组,各45例。于治疗前及治疗第1、2、4、8周末采用阳性与阴性症状量表（PANSS）评价临床疗效,副反应量表（TESS）评价不良反应。结果奎硫平组治疗有效率为75.6%高于利培酮组的73.3%,差异无统计学意义（P〉0.05）。奎硫平组锥体外系不良反应明显少于利培酮组（P〈0.05）,其他不良反应2组比较差异均无统计学意义（P〉0.05）。结论奎硫平治疗精神分裂症疗效肯定,不良反应少,依从性好。

Clinical study of quetiapine and risperidone in the treatment of schizophrenia

Objective To explore the effect and adverse reactions of quetiapine in the treatment of schizophrenia. Methods 90 schizophrenics who met schizophrenia were randomly diveded into the quetiapine（n = 45）and risperidone（n = 45）groups. Curative effects were assessed with the positive and negative rating scale（PANSS）,and side effects with the treatment emergent symptom scale（TESS）before treatment and at the ends of 1st,2nd,4th and 8th week of treatment. Results The effective rate of qutiapine group was 75. 6% higher than 73. 3% in risperidone group,which showed no significant difference （P 0. 05）. Extrapyramidal side effects of quetiapine group were fewer than those of risperidone group （P 0. 05）,there was no obvious difference in other factors of side effects between the 2 groups（P 0. 05）. Conclusion Quetiapine has better curative effect,fewer adverse reactions and better compliance in the treatment of schizophrenia.