金黄色葡萄球菌耐药性分析

目的了解金黄色葡萄球菌（SA）尤其是耐甲氧西林金黄色葡萄球菌（MRSA）的耐药状况,指导临床合理用药。方法对本院感染标本中分离的250株SA分别进行药敏实验和β-内酰胺酶测定,并对实验数据进行分析处理。结果MRSA占SA感染标本总数的50.0%;MRSA及甲氧西林金黄色葡萄球菌（MSSA）产β-内酰胺酶的百分率差异无统计学意义（P〉0.05）。MRSA与MSSA均对万古霉素敏感。此外,MRSA对15种抗生素中的12种呈多重耐药,耐药率为30.0%～100.0%;而多数MSSA仅对青霉素和氨苄西林耐药。结论万古霉素是治疗MRSA感染的首选抗生素。

Analysis of drug-resistant staphylococcus aureus

Objective To acquire the information about the present resistance characteristics in staphylococcus auras（SA）especially in methicillin-resistance in staphylococcus aureus（MRSA）,and to instruct rational application of antibiotics clinically.Methods 250 cases of SA collecting from infections sample in our hospital were carried out drug susceptibility testing and β-lactamase determination,and experimental data analysis and processing.Results SA infected with MRSA accounting for 50.0% of the total number of samples;Determination of β-lactamase production showed no significant differences between MRSA and methicillin-susceptible staphylococcus aureus（MSSA）.Both MRSA and MSSA were susceptible to vancomycin;MRSA showed multivesistance to 12 of 15 antibiotics with rates ranging from 30.0% to 100.0%,while most MSSA resistant only to penicillin ampicillin.Conclusion Vancomycin is the first choice antibiotics of MRSA infections.