埃索美拉唑治疗反流性食管炎疗效观察

目的观察埃索美拉唑治疗反流性食管炎（RE）的临床疗效。方法70例RE患者随机分为治疗组和对照组各35例,2组均应用莫沙比利治疗,治疗组加用埃索美拉唑;对照组加用奥美拉唑,疗程均为4周。观察2组症状缓解及胃镜下食管炎愈合情况。结果2组治疗后各症状评分均降低,与治疗前比较差异有统计学意义（P〈0.05）。且治疗组改善情况优于对照组,差异均有统计学意义（P〈0.05）。治疗组症状缓解总有效率为97.1%高于对照组的85.7%,差异有统计学意义（P〈0.05）。治疗组胃镜下食管炎愈合总有效率为94.3%高于对照组的74.3%,差异有统计学意义（P〈0.05）。结论埃索美拉唑治疗RE效果显著,可有效缓解症状,促进食管炎愈合。

Clinical effect observation of esomeprazole in treatment of reflux esophagitis

Objective To observe clinical effect of esomeprazole in treatment of reflux esophagitis.Methods 70 patients with reflux esophagitis were randomly divided into treatment group and control group,35 cases of each,the two groups were both applied mosapride treatment,the treatment group received esomeprazole,while the control group was treated with omeprazole,treatment for 4 weeks.Observed the two groups of symptoms alleviated and endoscopic esophagitis healing situation.Results The symptom score of the two groups were lower after treatment,compared with that before treatment was significantly（P0.05）.Improvements in treatment group were better than the control group,the differences were statistically significant（P0.05）.Symptom remission rate of treatment group was 97.1% higher than 85.7% of control group,the difference was significant（P0.05）.Healing of endoscopic esophagitis total effective rate was 94.3% higher than 74.3% of control group,the difference was statistically significant（P0.05）.Conclusion Esomeprazole treatment of reflux esophagitis can achieve significant results,effectively relieve symptoms and promote healing of esophagitis.