CD3−CD4−CD8−CD56−CD19−CD14− cells and CD3+CD8 dull-positive cells produce IL-4 in AIDS patients |
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| Authors: | Junichi Honda Yasumitsu Okubo Ken Tanaka Mikako Kusaba Mutsuko Kumagai Naoko Saruwatari & Kotaro Oizumi |
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| Institution: | First Department of Internal Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan |
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| Abstract: | We used flow cytometry to identify the presence of intracellular cytokines (cytoflow) and analyse the production of IL-4 in peripheral blood from AIDS patients who have practically no CD4+ T cells. We found that IL-4 was produced by CD3?CD4?CD8?CD56?CD19?CD14? cells and CD3+CD8 dull-positive cells in AIDS patients. Moreover, CD3?CD4? CD8?CD56?CD19?CD14? cells had helper activity for immunoglobulin synthesis. These findings indicate that instead of CD4+ T helper cells, C3?CD4?CD8?CD56? CD19?CD14? cells and CD3+CD8 dull-positive cells may be an important source of IL-4 in a variety of immune responses for AIDS patients. |
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| Keywords: | HIV CD4 IL-4 Th1 Th2 |
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