首页 | 本学科首页   官方微博 | 高级检索  
检索        


Serum levels of GM-CSF are elevated in patients with thrombocytopenia
Authors:Miguel  Abboud  Joseph  Laver  Fushen  Xu  Babette  Weksler & James  Bussel
Institution:Department of Pediatrics, Medical University of South Carolina, Charleston, S.C., and Departments of Medicine and Pediatrics, Cornell University Medical College, New York, N.Y., U.S.A.
Abstract:Serum levels of GM-CSF, IL-3 and IL-6 were measured in patients with immune thrombocytopenia (ITP), non-immune thrombocytopenia (NIT), autoimmune haemolytic anaemia (AIHA) and neutropenia. 8/10 children with ITP had elevated serum levels of GM-CSF (mean 18.4 pg/ml) while thrombocytopenic, but only two had detectable levels (mean 4.5 pg/ml) after normalization of the platelet count. In patients with NIT a significant inverse correlation between platelet count and serum levels of GM-CSF was observed. IL-3 and IL-6 levels were not significantly elevated in thrombocytopenic patients and only two of the nine patients with either AIHA or neutropenia had detectable levels of GM-CSF. Thus, GM-CSF may play a role in the response to severe thrombocytopenia.
Keywords:thrombocytopenia  GM-CSF  cytokines  neutropenia  haemolytic anaemia
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号