雷米普利、地高辛、利尿剂联用治疗慢性充血性心衰的临床观察

目的:比较雷米普利(ramipril)、地高辛、利尿剂合用与地高辛、利尿剂合用对慢性充血性心力衰竭(CHF)患者心功能、心率、心胸比率及左室射血分数(LVEF)的影响。方法:60例CHF患者随机分配至两个组,分别接受雷米普利、地高辛、利尿剂(简称雷米普利组)及地高辛加利尿剂(简称对照组),治疗12周。结果:两组患者治疗1周后、心率减慢与治疗前相比有显著差异(P<0.01),雷米普利组治疗12周与治疗1周相比、心率减慢仍有显著差异(P<0.01),而对照组则改善不显著(P>0.05);雷米普利组治疗12周后心胸比率缩小,LVEF提高较治疗前有非常显著差异(P<0.01),而对照组治疗后LVEF提高较治疗前无显著性差异(P>0.05)。结论:雷米普利、地高辛、利尿剂联用对CHF患者心率减慢、心胸比率缩小、LVEF提高的疗效较好。

A Clinical Observation of Ramipril, Digoxin, Diuretic Combine Medication on Treatment of Chronic Con-gestive Heart Failure

Objective: To Compare the effects of Ramipril, Digoxin and Diuretic with Digoxin and Diuretic on cardiac function, heart rate, cardio-thoracic ratio and left ventricular ejection fraction (LVEF) in chronic congestive heart failure (CHF) patients. Methods: Sixty patients were allocated randomly into two groups , one group received Ramipril, Digoxin and Diuretic, and the other group received Digoxin and Diuretic as control group, for 12 weeks. Results: The heart rate were lower significantly in both groups after treatment of one week (P<0.01), the cardio-thoracic ratio reduced, LVEF increased significantly(P<0.05) in ramipril group after 12 weeks treatment, while no significant changes in control group (P>0.05). Conclusions: Ramipril, Digoxin and Diuretic is more effective than Digoxin and Diuretic treatment on heart rate reduction, cardio-thoracic ratio decrease, LVEF increase in CHF patiens.