海捷亚治疗原发性高血压的临床观察

目的；观察海捷亚（氯沙坦钾／氢氯噻嗪片）对原发性高血压患者的降压疗效及不良反应。方法：为自身对照方式的多中心研究。选择490例Ⅰ，Ⅱ级原发性高血压病例，服海捷亚（每天晨服一例）共4周，观察用该药期间血压、心率及不良反应情况。结果：服海捷亚1周起，收缩压、舒张压、平均动脉压均显著下降（P＜0.01)，至第4周降压幅度最显著（P＜0．001）。海捷亚对老年高血压与较年轻高血压患者同样有效。结论：海捷亚能有效控制血压，不良反应少。

Effects of HYZAAR on Treatment of Essential Hypertension

To observe antihypertensive effect of HYZAAR (losastan potessium/hy-drochlerothiazide) in essential hypertension patients. Methods: This was a multicenter and follow-up study, 490 patients with mild-to-moderate hypertension were received HYZAAR 1 tablet per day for 4 weeks. Blood pressure, heart rate were measured. Side effects were observed. Results: SBP, DBP and MAP were significantly reduced at the first week (P<0.01) and the reduction at the forth week was the most remarkable (P < 0.001). HYZAAR was an effective drug for both elderly and younger patients. Conclusions: HYZAAR is an effective and safe agent in treatmen of Essential hypertension.