| PRAME在儿童急性白血病诊疗中的研究进展 |
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| 引用本文： | 聂莹.PRAME在儿童急性白血病诊疗中的研究进展[J].国际儿科学杂志,2010,37(4). |
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| 作者姓名： | 聂莹 |
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| 作者单位： | 第四军医大学西京医院小儿科,西安,710032 |
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| 基金项目： | 陕西科学技术研究发展计划项目 |
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| 摘 要： | 黑色素瘤特异性抗原(preferentially expressed antigen of melanoma,PRAME)基因作为泛白血病标志可用于微小残留白血病检测,并对疗效、预后、危险度分级及复发预测具有一定意义.此外,PRAME作为肿瘤相关抗原,可被细胞毒性T细胞识别,是白血病免疫治疗的理想靶点,对PRAME基因启动子区CpG岛甲基化的深入研究有助于理解PRAME基因在白血病中的表达机制及与白血病发生之间的关系.
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| 关 键 词： | 黑色素瘤特异性抗原 微小残留白血病 免疫治疗 甲基化 |
Development of PRAME in the diagnosis and treatment of children acute leukemia |
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| NIE Ying.Development of PRAME in the diagnosis and treatment of children acute leukemia[J].International Journal of Pediatrics,2010,37(4). |
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| Authors: | NIE Ying |
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| Abstract: | The gene of preferentially expressed antigen of melanoma(PRAME) is a gene marker of leukemia,which can be used to monitor the minimal residual disease,and can make us to comprehend the curative effect,prognosis,the grade of risk and can predict relapse.In addition,PRAME as a human tumour antigen,can be recognized by autologous cytolytic T lymphocytes,is a ideal target of immunotherapy in leukemia,and investigate the methylation level of PRAME gene CpG island,which can help us comprehend the relation of the mechanism of PRAME and leukemia. |
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| Keywords: | PRAME Minimal residual disease Immunotherapy Methylation |
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