| 新维生素甲酸衍生物抑制小鼠前胃鳞状上皮癌变的研究 |
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| 引用本文： | 蔡海英,张金生,崔小邢. 新维生素甲酸衍生物抑制小鼠前胃鳞状上皮癌变的研究[J]. 药学学报, 1981, 16(9): 648-653 |
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| 作者姓名： | 蔡海英 张金生 崔小邢 |
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| 作者单位： | 中国医学科学院肿瘤研究所化学病因室 北京(蔡海英，张金生)，中国医学科学院肿瘤研究所化学病因室 北京(崔小邢) |
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| 摘 要： | 本文报道9种维生素甲酸衍生物对小鼠前胃上皮癌变的影响,其中有抑制作用的有:RⅠ、RⅡ、RⅢ、RⅥ及RⅧ,尤以RⅠ[N-(4-乙氧羰基苯基)维甲酰胺][N-(4-Ethoxycarbophenyl)Retinamide]抑制上皮癌变作用明显,并可重复,文献上未见报道。RⅠ在治疗剂量下(1.1×10-4M/kg)未出现毒性,六倍于治疗剂量,亦未见高维生素甲症,而相应剂量的维甲酸,引起明显的高维生素甲症,RⅠ毒性远较维甲酸小。用氚—胸腺嘧啶核苷放射自显影方法,观察到RⅡ对小鼠前胃上皮细胞DNA合成有明显的抑制作用。
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| 收稿时间： | 1980-04-01 |
INHIBITORY EFFECT OF SOME NEW RETINOIDS ON CARCINOGENESIS |
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| Cai Haiying,Zhang Jinsheng and Cui Xiaoxing. INHIBITORY EFFECT OF SOME NEW RETINOIDS ON CARCINOGENESIS[J]. Acta pharmaceutica Sinica, 1981, 16(9): 648-653 |
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| Authors: | Cai Haiying Zhang Jinsheng Cui Xiaoxing |
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| Abstract: | Effects of nine retinoids on carinogenesis of the forestomach in mice were studied. RⅠ, RⅡ, RⅢ, RⅥ, and RⅧ showed significaut inhibitory effect. RⅠ[N-(4-ethoxycarbophenyl) Retinanide] appeared to be the most effective, reproducible and has not been reported in the literature. No toxic effect was observed with therapeutic dose of RⅠ, and no sign of hypervitaminosis A was noticed with dosage as high as 6 times the therapeutic dose. However hypervitamnosis A was induced with retinoic acid at the some dose. The toxiciity of RⅡ appeared to the much less than that of retinoic acid.Autoradiography using H3-thymidine showed marked inhibitory effect of RⅡ on DNA synthesis in the forestomach epithelium of mice. |
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