| 可切除胰腺癌的围手术期治疗与全程管理 |
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| 引用本文： | 黄惠颖,曹宝山. 可切除胰腺癌的围手术期治疗与全程管理[J]. 中国肿瘤临床, 2021, 48(2): 85-92. DOI: 10.3969/j.issn.1000-8179.2020.02.038 |
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| 作者姓名： | 黄惠颖 曹宝山 |
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| 作者单位： | 北京大学第三医院肿瘤化疗与放射病科（北京市100191） |
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| 基金项目： | 国家卫生健康委员会国家重大疾病多学科合作诊疗能力建设项目资助。 |
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| 摘 要： | 胰腺癌是恶性程度和致死率极高的消化道恶性肿瘤.可切除胰腺癌是指可以通过手术达到根治性切除的胰腺癌,临床研究表明辅助化疗能延长可切除胰腺癌患者的生存期,但总体预后仍不乐观.目前国内缺乏一套规范的可切除胰腺癌患者全程管理模式.本文通过对可切除胰腺癌近20年来辅助治疗、新辅助治疗、分子靶向治疗、靶向肿瘤微环境的治疗如免疫治疗...
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| 关 键 词： | 可切除胰腺癌 辅助治疗 新辅助治疗 分子靶向治疗 肿瘤微环境 |
| 收稿时间： | 2020-08-31 |
Perioperative treatment and management of resectable pancreatic cancer |
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| Huiying Huang,Baoshan Cao. Perioperative treatment and management of resectable pancreatic cancer[J]. Chinese Journal of Clinical Oncology, 2021, 48(2): 85-92. DOI: 10.3969/j.issn.1000-8179.2020.02.038 |
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| Authors: | Huiying Huang Baoshan Cao |
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| Affiliation: | Department of Medical Oncology and Radiation Sickness, Cancer Center, Peking University Third Hospital, Beijing 100191, China |
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| Abstract: | Pancreatic cancer(PC)is a type of digestive tract cancer that is associated with high rates of malignancy and mortality.Resectable PC(RPC)is a type of PC that can be surgically resected.In recent years,clinical research has revealed that the overall survival(OS)of patients with RPC treated with adjuvant chemotherapy is prolonged.However,the overall prognosis is still not optimistic.Currently,there is no standard management protocol that is suitable for Chinese patients with RPC.Therefore,this study reviewed therapeutic strategies such as adjuvant and neoadjuvant chemotherapy;molecular-targeted therapy;new treatments targeting tumor microenvironments,including immunotherapy and tumor vaccines;and therapies targeting special types of RPC during the past 20 years to provide a standard clinical management protocol for Chinese patients with RPC. |
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| Keywords: | resectable pancreatic cancer(RPC) adjuvant therapy neoadjvant therapy molecule-targeted therapy tumor microenvironment |
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