炎症因子介导乙型肝炎病毒感染后机体免疫反应的研究进展

乙型肝炎病毒(HBV)感染后,病毒在人体内复制导致细胞损伤,从而激活体内免疫细胞释放炎症因子,进一步加重肝损伤。肝脏炎症损伤涉及多种免疫细胞,其分泌的炎症因子在细胞和体液免疫反应、抗病毒活性、病毒清除、细胞凋亡和纤维化形成等过程中发挥着至关重要的作用。HBV感染后,多种免疫细胞和炎症因子相互作用,形成复杂的免疫反应网络,从而促进肝炎的发生发展。炎症因子是HBV感染后引起炎症和肝损伤的主要原因,本文将对HBV感染后相关炎症因子在HBV发展和肝损伤中作用机制的研究进展进行综述,以期为乙型肝炎的防治提供参考。

Research progress in inflammatory factor-mediated HBV infection

After hepatitis B virus (HBV) infection, the virus replicates in the human body and causes cell damage, which activates the release of inflammatory factors in immune cells and further aggravates liver damage. Inflammatory liver damage involves a variety of immune cells, and the inflammatory factors secreted by them play a vital role in cellular and humoral immune responses, antiviral activity, virus clearance, apoptosis and fibrosis formation. HBV infection leads to interaction between a wide array of immune cells and inflammatory factors, forming a complex immune response network and thus promoting the occurrence and development of hepatitis. Inflammatory factors are the main cause of inflammation and liver damage after HBV infection. This article reviews the research progress in the mechanism of inflammatory factors involved in HBV development and liver damage after HBV infection in a view to providing reference for the prevention and treatment of hepatitis B.