| 肌少症与认知障碍的共同生物标志物研究 |
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| 引用本文： | 杨文丽,蒋倩雯,李菲卡,吴方. 肌少症与认知障碍的共同生物标志物研究[J]. 中华老年多器官疾病杂志, 2022, 21(6): 460-463 |
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| 作者姓名： | 杨文丽 蒋倩雯 李菲卡 吴方 |
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| 作者单位： | 上海交通大学医学院附属瑞金医院老年病科,上海200025,上海交通大学医学院附属瑞金医院老年病科,上海200025,上海交通大学医学院附属瑞金医院老年病科,上海200025,上海交通大学医学院附属瑞金医院老年病科,上海200025 |
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| 基金项目： | 国家重点研发项目(2018YFC2002101)；上海市卫生健康委员会卫生行业临床研究项目(202040088) |
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| 摘 要： | 肌少症及认知障碍是两大常见的老年综合征，两者互为因果，肌少症使认知障碍的患病风险增加，认知障碍也可引起肌少症，最终形成恶性循环关系。早期识别肌少症和认知障碍并对其进行干预，对改善老年患者的生活质量至关重要。而生物标志物较临床表型更早出现于机体。因此，本文从炎症、激素、营养及生长因子四个方面对肌少症和认知障碍的潜在共同生物标志物进行初步探讨，以期客观及时识别肌少症和认知障碍个体。
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| 关 键 词： | 肌少症 认知障碍 生物标志物 |
| 收稿时间： | 2021-06-25 |
Research on common biomarkers of sarcopenia and cognitive impairment |
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| YANG Wen-Li,JIANG Qian-Wen,LI Fei-Ka and WU Fang. Research on common biomarkers of sarcopenia and cognitive impairment[J]. Chinese Journal of Multiple Organ Diseases in the Elderly, 2022, 21(6): 460-463 |
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| Authors: | YANG Wen-Li JIANG Qian-Wen LI Fei-Ka WU Fang |
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| Affiliation: | Department of Geriatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China,Department of Geriatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China,Department of Geriatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China and Department of Geriatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China |
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| Abstract: | Sarcopenia and cognitive impairment, two common geriatric syndromes, have mutual causality. Sarcopenia increases the risk of cognitive impairment, and cognitive impairment can also cause sarcopenia, eventually developing into a vicious cycle. Early recognition and intervention of sarcopenia and cognitive impairment are crucial to improve the quality of life of the elderly patients. Biomarkers appear earlier in the body than clinical phenotypes. Therefore, this paper preliminarily discusses the potential common biomarkers of sarcopenia and cognitive impairment from four aspects, including inflammation, hormone, nutrition and growth factors, helping objective and timely identification of individuals with sarcopenia and cognitive impairment. |
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| Keywords: | sarcopenia cognitive impairment biomarker This work was supported by National Key Research and Development Program of China |
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