| 髓源性抑制细胞在肿瘤发生发展中的作用 |
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| 引用本文： | 王茜,李雁.髓源性抑制细胞在肿瘤发生发展中的作用[J].中国肿瘤临床,2021,48(2):73-78. |
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| 作者姓名： | 王茜 李雁 |
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| 作者单位： | 上海中医药大学附属市中医医院肿瘤科（上海市200071） |
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| 基金项目： | 国家自然基金面上项目(编号:81673947,81973795)资助。 |
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| 摘 要： | 髓源性抑制细胞(myeloid-derived suppressor cells,MDSCs)是一组异质细胞,在肿瘤相关免疫抑制中起关键作用.MDSCs通过免疫抑制作用,使肿瘤逃避免疫监控.肿瘤组织中MDSCs的浸润与患者预后不良及治疗的抵抗密切相关.MDSCs在转移中发挥重要作用,但MDSCs在远处器官建立转移前微环...
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| 关 键 词： | 髓源性抑制细胞 肿瘤 转移前微环境 自噬 |
| 收稿时间： | 2020-08-26 |
Role of myeloid-derived suppressor cells in tumorigenesis and tumor development |
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| Xi Wang,Yan Li.Role of myeloid-derived suppressor cells in tumorigenesis and tumor development[J].Chinese Journal of Clinical Oncology,2021,48(2):73-78. |
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| Authors: | Xi Wang Yan Li |
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| Institution: | Department of Oncology, Municipal Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200071, China |
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| Abstract: | Myeloid-derived suppressor cells(MDSCs)are a heterogeneous group of cells that play a critical role in tumor-associated immune suppression.MDSCs allow tumors to evade immune surveillance through immunosuppressive effects.The infiltration of MDSCs into cancer tissues is associated with poor prognosis and resistance to therapies.MDSCs play an important role in metastasis,but the mechanism by which MDSCs establish the pre-metastatic microenvironment in distant organs is largely unknown.This article reviews the role of MDSCs in cancer development and progression and the related mechanisms through which MDSCs participate in the formation of the pre-metastatic niche.The potential therapeutic value of MDSCs in tumor development and progression was also investigated. |
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| Keywords: | myeloid-derived suppressor cells(MDSCs) cancer pre-metastases niche autophagy |
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