溃疡性结肠炎患者C反应蛋白/白蛋白比值与疾病活动性的相关性研究

溃疡性结肠炎(ulcerative colitis,UC)是一种由环境因素和遗传因素共同作用的慢性、非特异性肠道炎性反应性疾病。近年来UC发病率逐渐升高,已成为全球性健康问题1]。早期发现UC活动性不仅对该病治疗具有重要意义,还可以有效预防并发症,从而改善预后和生活质量2-3]。尽管目前已有许多生物标志物用于评估UC的活动性4-7],但临床诊断价值不明确,内镜检查仍然是目前诊断和评估UC患者疾病活动性的金标准。因此,临床上亟需一种经济有效、非侵入性的生物标志物用于评估UC的活动性。

The relationship between C-Reactive protein/albumin ratio and disease activity in patients with ulcerative colitis

Objective To evaluate the C-reactive protein/albumin ratio (CRP/ALB), inflammatory markers and complete blood count (CBC) parameters in patients with ulcerative colitis (UC) and their relationship with disease activity. Methods A retrospective analysis of 183 cases of ulcerative colitis (UC) with serum C-reactive protein (CRP), albumin (ALB), erythrocyte sedimentation rate (ESR) and CBC parameters was taken during January 2015 to December 2020. The Mayo score was used to evaluate the disease activity of UC patients. The relationship between the above parameters and disease activity was discussed. Results The CRP/ALB ratio, CRP, ESR, platelet/lymphocyte ratio (PLR), red blood cell distribution width (RDW), neutrophil/lymphocyte ratio (NLR) of patients with active UC were significantly higher than those of patients with stable UC, while ALB and lymphocyte/monocyte ratio (LMR) were significantly lower than that of patients with stable UC (P<0.001).The CRP/ALB ratio was strongly correlated with different levels of UC activity (r>0.6, P<0.001).ROC curve analysis results showed that the best cut-off value of CRP/ALB ratio for active UC was 0.17, the sensitivity was 67.9%, the specificity was 86.5% and the Youden index was 0.544. Multivariate logistic regression analysis showed that after adjusting these inflammatory markers (ESR, NLR, PLR, and LMR), the CRP/ALB ratio was a significant parameter to distinguish the disease activity of UC. Conclusion The CRP/ALB ratio level is closely related to UC disease activity, and there is a strong positive correlation, which can be used to evaluate UC disease activity.