2型糖尿病患者的肾糖阈及相关因素分析

目的:探讨2型糖尿病患者肾糖阈水平及相关因素。方法:选取本院内分泌科住院的107例2型糖尿病患者，以正常肾糖阈值(RT G, 8.9～10 mmol/L)为切点，将患者分为高RT G组(RT G>10 mmol/L)、中等RT G组(8.9 mmol/L≤RT ...

Analysis of renal glucose threshold and related factors in patients with type 2 diabetes mellitus

Objective To investigate the value of renal glucose threshold and related factors in patients with type 2 diabetes mellitus.Methods According to the cut-off point of normal renal glucose threshold(RTG 8.9-10 mmol/L),107 patients with type 2 diabetes mellitus hospitalized in the Endocrinology Department of our hospital were divided into three groups:high RTG group(RTG>10 mmol/L),medium RTG group(8.9 mmol/L≤RTG≤10 mmol/L),and low RTG group(RTG<8.9 mmol/L).The clinical data and biochemical characteristics of each group were collected and analyzed.Results The proportions of patients with high,medium,and low RTG of type 2 diabetes mellitus were 56%,29%,and 15%,respectively.There were significant differences in RTG value,age,course of disease,body mass index(BMI),fasting plasma glucose(FPG),HbA1C,total cholesterol(TC),serum creatinine,mean blood glucose(MBG),and 24-hour urine glucose between high and medium RTG groups.RTG,gender,BMI,FPG,HbA1C,TC,and MBG in patients with high RTG group were different from those in low RTG group.Only RTG revealed a difference between medium and low RTG groups.Correlation analysis showed that RTG was positively correlated with gender,age,BMI,HbA1C,TC,and low density lipoprotein-cholesterol(LDL-C).Regression analysis showed that BMI,HbA1C,and LDL-C were the related factors affecting the RTG of patients with type 2 diabetes.Conclusion There is a larger proportion of patients with high RTG in type 2 diabetes mellitus.Their BMI,HbA1C,and LDL-C are associated with RTG in the patients with type 2 diabetes mellitus.