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Anti-cancer activity of a novel palladium(II) complex on human breast cancer cells in vitro and in vivo |
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| Authors: | Ulukaya Engin Ari Ferda Dimas Konstantinos Ikitimur Elif Ilkay Guney Emel Yilmaz Veysel T |
| Affiliation: | a Uludag University, Medical School, Department of Medical Biochemistry, Bursa, Turkey b Uludag University, Faculty of Arts and Sciences, Department of Biology, Bursa, Turkey c University of Thessaly, School of Medicine, Department of Pharmacology, Biopolis, Larisa, Greece d Istanbul University, Faculty of Veterinary Medicine, Department of Animal Breeding and Husbandry, Istanbul, Turkey e Uludag University, Faculty of Arts and Sciences, Department of Chemistry, Bursa, Turkey |
| Abstract: | Anti-cancer effects of a newly-synthesized palladium(II) complex, [Pd(sac)(terpy)](sac)·4H2O (sac = saccharinate, and terpy = 2,2′:6′,2″-terpyridine), were tested against human breast cancer cell lines, MCF-7 and MDA-MB-231. The Pd complex had a strong anti-growth effect in a dose- and time-dependent manner in vitro. This effect was also confirmed by the experiment performed on Balb/c mice in vivo. The IC50 values were 0.09 μM for MDA-MB-231 and 3.05 μM for MCF-7. It was also very effective in disrupting the formation of MDA-MB-231 tubules on matrigel, indicative of a putative anti-invasive activity. It induced apoptosis via the cell death genes of DR4 and DR5. In conclusion, this newly-synthesized Pd (II) complex represents a potentially active novel drug for the breast cancer treatment. |
| Keywords: | Palladium(II) complex Breast cancer Cytotoxicity Apoptosis Treatment |
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