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Les lymphocytes TH17 : différenciation, phénotype, fonctions, et implications en pathologie et thérapeutique humaine |
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| Authors: | M Samson D Lakomy S Audia B Bonnotte |
| Institution: | a Service de médecine interne et immunologie clinique, hôpital du Bocage, CHU de Dijon, 2, boulevard Maréchal-de-Lattre-de-Tassigny, 21079 Dijon cedex, France b Laboratoire d’immunologie, plateau technique de biologie, hôpital du Bocage, CHU de Dijon, 2, boulevard Maréchal-de-Lattre-de-Tassigny, 21079 Dijon cedex, France c Centre de recherche Inserm 866, faculté de médecine, 7, boulevard Jeanne-d’Arc, 21034 Dijon cedex, France |
| Abstract: | Differentiation of naive CD4+ T helper (TH) cells is a major step of the adaptative immune response. When activated by pathogens in a specific cytokine environment, CD4+ T cells differentiate into different subsets of TH cells with specific effector functions. TH1 lymphocytes orchestrate cellular immune response by producing interferon-γ and stimulating cytotoxic cells whereas TH2 cells orchestrate humoral immune response by producing interleukin-4 (IL-4), IL-5 and IL-10, leading to immunoglobulin production. Conversely, regulatory T cells (Treg) are capable of inhibiting immune response. Recently discovered, TH17 cells are characterized by their ability to produce IL-17 and play an important role in anti-infectious and inflammatory immune responses. This review focuses on present knowledge about TH17 cells: their induction, phenotype, functions, implications in host defense and human disease, and their potential to represent possible therapeutic targets. |
| Keywords: | Ré ponse immunitaire Lymphocytes TH17 Auto-immunité |
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