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Synthesis and anti-microbial activity of some 1- substituted amino-4,6-dimethyl-2-oxo-pyridine-3-carbonitrile derivatives |
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| Authors: | Khidre Rizk E Abu-Hashem Ameen A El-Shazly Mohamed |
| Affiliation: | a Chemical Industries Division, National Research Centre, Dokki 12622, Giza, Egypt b Department of Photochemistry, National Research Centre, Dokki 12622, Giza, Egypt c Chemistry department, Faculty of Science, Jazan University, Saudi Arabia d Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt |
| Abstract: | A new series of 1- substituted amino-4,6-dimethyl-2-oxo-pyridine-3-carbonitrile such as hydrazide hydrazones 3a-h; ethane-1,2-diaminopyridine 6; phthalimidopyridines 8a,b; hydrazides 10a,b; urea 11a and thiourea 11b were synthesized in a good to excellent yield in step efficient process, using 1-amino-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (1) as a key intermediate. The antibacterial and antifungal activities of the synthesized compounds were evaluated. The obtained data indicated that the majority of the tested compounds exhibited both antibacterial and antifungal activities, particularly compounds 8a and 8b showed a comparable effect to a well known antibacterial and antifungal agents. |
| Keywords: | Pyridines Hydrazide hydrazones Urea and thiourea derivatives Anti-microbial and antifungal activities Structure-activity relationship (SAR) |
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